Stefano Evangelista Selected Research

octylonium (otilonium bromide)

1/2018	Otilonium Bromide: A Drug with a Complex Mechanism of Action.
1/2017	Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress.
9/2008	Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.
12/2002	The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.
12/2002	Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome.

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Stefano Evangelista Research Topics

Disease

8	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2018 - 12/2002
6	Hypertension (High Blood Pressure) 04/2014 - 02/2006
2	Pain (Aches) 01/2015 - 12/2002
2	Atherosclerosis 01/2008 - 10/2002
2	Constipation 05/2007 - 12/2002
1	Abdominal Pain (Pain, Abdominal) 01/2018
1	Myocardial Infarction 01/2016
1	Ischemia 01/2016
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2016
1	Reperfusion Injury 01/2016
1	Pruritus (Itching) 01/2015
1	Neuralgia (Stump Neuralgia) 01/2015
1	Hyperalgesia 01/2015
1	Dyspepsia (Indigestion) 01/2015
1	Thrombosis (Thrombus) 04/2014
1	Pulmonary Embolism 04/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013
1	Hypertrophy 11/2011
1	Cough 12/2010
1	Heart Failure 08/2010
1	Atrophy 08/2010
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 05/2010
1	Vomiting 12/2009
1	Cardiotoxicity 05/2009
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/2008
1	Polyuria 08/2008
1	Vascular Remodeling 01/2008
1	Inflammation (Inflammations) 01/2008
1	Fibrosis (Cirrhosis) 12/2007
1	Gastroesophageal Reflux (GERD) 05/2007
1	Urinary Incontinence 07/2005
1	Schizophrenia (Dementia Praecox) 07/2005
1	Ulcer 01/2004
1	Stomach Ulcer (Gastric Ulcer) 01/2004

Drug/Important Bio-Agent (IBA)

5	octylonium (otilonium bromide)IBA 01/2018 - 12/2002
5	Pharmaceutical PreparationsIBA 01/2018 - 12/2002
5	zofenoprilIBA 01/2016 - 02/2006
4	Parasympatholytics (Antispasmodics)IBA 01/2018 - 09/2008
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016 - 02/2006
4	Nebivolol FDA Link 04/2014 - 12/2007
4	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2010 - 10/2002
3	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 06/2013 - 02/2006
2	AntioxidantsIBA 11/2011 - 01/2008
2	Proteins (Proteins, Gene)FDA Link 08/2010 - 01/2008
2	Metalloproteases (Metalloproteinases)IBA 01/2008 - 01/2004
2	Atenolol (Tenormin)FDA LinkGeneric 01/2008 - 12/2007
1	Ammonium CompoundsIBA 01/2018
1	Cholinergic Agents (Cholinergics)IBA 01/2018
1	Tachykinin Receptors (Tachykinin Receptor)IBA 01/2018
1	Troponin IIBA 01/2016
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2016
1	Capsaicin (Zostrix)FDA Link 01/2015
1	Bisoprolol (Concor)FDA LinkGeneric 04/2014
1	CollagenIBA 04/2014
1	Epinephrine (Adrenaline)FDA LinkGeneric 04/2014
1	Angiotensin IIIBA 10/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2013
1	Citric Acid (Citrate)FDA LinkGeneric 12/2010
1	Ramipril (Altace)FDA LinkGeneric 12/2010
1	AerosolsIBA 12/2010
1	ProstaglandinsIBA 12/2010
1	BradykininIBA 12/2010
1	zofenoprilateIBA 12/2010
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 12/2010
1	ramiprilatIBA 12/2010
1	Protein Isoforms (Isoforms)IBA 08/2010
1	SphingosineIBA 08/2010
1	Aprepitant (Emend)FDA Link 12/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2009
1	E-SelectinIBA 01/2008
1	oxidized low density lipoproteinIBA 01/2008
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2008
1	Thromboplastin (Tissue Factor)IBA 01/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008
1	P-SelectinIBA 01/2008
1	Endothelin-1 (Endothelin 1)IBA 01/2008
1	Collagen Type I (Type I Collagen)IBA 12/2007
1	PumosetragIBA 05/2007
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 02/2006
1	DiureticsIBA 02/2006
1	Enalapril FDA LinkGeneric 02/2006
1	SB 223412IBA 07/2005
1	RNA (Ribonucleic Acid)IBA 01/2004
1	Matrix Metalloproteinase 3 (Stromelysin 1)IBA 01/2004
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2004
1	Tissue Inhibitor of Metalloproteinase-1IBA 01/2004
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2004
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 01/2004
1	Matrix Metalloproteinases (MMPs)IBA 01/2004

Therapy/Procedure

2	Therapeutics 01/2015 - 08/2008
1	Intravenous Injections 04/2014
1	Drug Therapy (Chemotherapy) 12/2009